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In the PCOS ovarian microenvironment, key functional cells such as granulosa cells are particularly vulnerable to this pathway, which directly impairs follicular development and maturation

This suggests that additional clinical or contextual factors likely contribute to side-effect burden and should be examined in future work

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supplementation in older adults has shown reduced oxidative stress in tissues and possibly improved endothelial function ( However, trials of single antioxidant supplements for extending lifespan in humans have largely been disappointing

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